[Bringing attention to this article originally posted Jan. 29th since today it was posted as the Editor's Choice.]
Abstract
Objectives
To explore current evidence of the physiological embedding of stress to discuss whether adverse childhood experiences (ACE) causing chronic or acute stress responses may alter fundamental biological functions....
Results
These mechanisms, in interaction with social position, and mediated by subsequent environmental exposures, may ultimately lead to the development of cancer. The experience of acute or chronic stressors during sensitive periods of childhood development which can induce several known biological responses, are likely to have an impact on subsequent biological and behavioural functions depending on the timing of initial exposures, and subsequently mediated by later exposures. For this reason, childhood exposure to adversity is a likely source of both acute and chronic stressors, and can be examined as an important initial exposure on a pathway towards adult ill health.
Conclusions
Such pathways justify a life course approach to understanding cancer aetiology, which may have its origins early in life.
http://link.springer.com/article/10.1007/s00038-012-0370-0#
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Kelly-Irving, et al. International Journal of Public Health February 2013, Volume 58, Issue 1, pp 3-11
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