"New research shows that in a dynamic mind-body interaction during the interpretation of prolonged stress, cells from the immune system are recruited to the brain and promote symptoms of anxiety.
"The findings, in a mouse model, offer a new explanation of how stress can lead to mood disorders and identify a subset of immune cells, called monocytes, that could be targeted by drugs for treatment of mood disorders....
"Our data alter the idea of the neurobiology of mood disorders," said Eric Wohleb, first author of the study and a predoctoral fellow in Ohio State's Neuroscience Graduate Studies Program. "These findings indicate that a bidirectional system rather than traditional neurotransmitter pathways may regulate some forms of anxiety responses. We're saying something outside the central nervous system – something from the immune system – is having a profound effect on behavior."
http://medicalxpress.com/news/2013-08-mood-immune-cells-brain-response.html
Wohleb, et al. (2013). "Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior." Journal of Neuroscience. Abstract.
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