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Genetic and Environmental Determinants of Biobehavioral Health

I just got my CD of the 25th annual Boston Trauma Conference (BVK).  I am listening to differential gene expression in peer reared versus mother reared rhesus monkey studies.  I don't know if we can get a group ACEs subscription to this work... I may check it out for ACEs subscribers.... But I am shocked. As shocked as I was when I first learned of Harlow's Monkey experiments in 2001.   Work by: 

  • Stephen J. Suomi, PhD, Head, Comparative Behavior Genetics Section (this researchers work needs more research by ACErs)..in my opinion!!!

 

 

Genes that are thought to promote certain negative behaviors such as drinking too much as an adolescent ---- are protective if the monkey is mother reared versus peer reared. In fact 25 percent (1/4) of the entire genome of the rhesus monkey is differentially methylated (i.e. expressed) vs not expressed at age 8 in these monkeys depending on whether they are peer vs mother reared. Environment matters!!! This is astounding.  So what we think may genetically be the problem gene (or many researchers in big academic centers)--- is protective in the right environment. If anyone has the most recent published data to this work... I would like to see it.... 

 

Thanks

 

http://cmbconference2012.org/b...riences-in-primates/

http://www.thefpr.org/private/pdf/BROWNC~1.pdf

http://annualreport.nichd.nih.gov/suomi.html

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Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells

 

He is also doing research on the cycle of inter-generational transmission. I am still amazed, even more amazed.  This work needs to be studied because now I am listening to how mothers can change the intergenerational transmission.  It is amazing. He is showing a video of how a low ranking mother who sees a troupe fight - grabs a dandy lion flower and she looks eye to eye in her infants eye ( to distract the infant from going to run to the event --- the infant saw it initially and was about to run).  The mother seemed to know that if her infant went to that incident ---- there may be trouble.   I am so amazed and even stunned by the low ranking mother's behavior to keep her infant out of trouble, and safe and gave the baby face to face time... It is beautiful....

 

http://www.sciencedirect.com/s...ii/S1873506114000361

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