For several years now, SSRIs (Selective Serotonin Re-uptake Inhibitors" have been so-called first rank treatments for not only Depression (at least for certain degrees of severity) but for PTSD -- such as from psychological trauma. This is especially important to re-consider now, after not only the Culverhouse meta-analysis previously discussed on this site; but also after some recent research from Jakobsen et al from Denmark:
"Per our results, we now believe that there is valid evidence for a public concern regarding the effects of SSRIs. We agree with Andrews et al. that that antidepressants seem to do more harm than good [206]. We have clearly shown that SSRIs significantly increase the risks of both serious and several non-serious adverse events. The observed harmful effects seem to outweigh the potential small beneficial clinical effects of SSRIs, if they exist. Our results confirm the findings from other studies questioning the effects of SSRIs [8, 207], but are in contrast to the results of other reviews concluding that SSRIs are effective interventions for depression [3, 6, 10, 208]. However, our present analyses represent the most comprehensive systematic review on the topic and we hope it may guide clinical practice."
The article is available, in full, here:
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