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Childhood trauma torpedoes alcohol protection [NorthDenverNews.com]

While the influence of heritable factors on the development of alcohol use disorders (AUDs) has been documented in family pedigree and twin studies for decades, identification of specific genetic variants that influence AUDs continues to be challenging. The ADH1B gene has consistently been implicated in problem drinking, but rarely incorporated into gene/environment investigations of alcohol phenotypes. A study examining the joint effects of variation in ADH1B and childhood adversity on heaviness of alcohol consumption and AUD symptoms has found that, under conditions of childhood adversity, the genetic variant on the ADH1B allele that typically protects against problem drinking does not exert its protective effects in European-American men.

 

[For more of this story go to http://northdenvernews.com/chi...-alcohol-protection/]

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