Association of Neighborhood-Level Disadvantage With Alzheimer Disease Neuropathology [jamanetwork.com]

Rafael Maravilla(PACEs Connection Staff) 6/13/2012:00 PM

By W. Ryan Powell, William R. Buckingham, Jamie L. Larson, et al., JAMA Network Open, June 11, 2020

Key Points

Question Can neighborhood disadvantage, a social determinant of health, be incorporated into existing brain bank data to evaluate the risk of biological outcomes, such as Alzheimer disease neuropathology?

Findings In this cross-sectional study using autopsy samples from 447 decedents, living in a disadvantaged neighborhood at the time of death was associated with an increased risk of presence of Alzheimer disease neuropathology when adjusting for age, sex, and year of death.

Meaning These findings suggest that neighborhood disadvantage can be geolinked to brain bank repositories and may be a marker for Alzheimer disease neuropathology.

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