By Line J.H. Rasmussen, Terry E. Moffit, et al., JAMA Pediatrics, November 4, 2019
Question: Is exposure to adverse experiences, stress, and violence in childhood associated with an increase in blood levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor in young people?
Findings: In this cohort study of 1391 young people followed up to 18 years of age in the United Kingdom, exposure to adverse experiences, stress, and violence during childhood or adolescence was associated with elevated levels of the soluble urokinase plasminogen activator receptor at 18 years of age, even in children who did not have elevated C-reactive protein or interleukin 6 levels.
Meaning: The findings suggest that stress-related inflammation begins at a relatively young age, and the measurement of this inflammatory burden may be improved by adding information about soluble urokinase plasminogen activator receptor to traditional biomarkers of inflammation.